Can You Use Peptides and Vitamin C Together? Everything You Need To Know

Written by Drilon Beloshi | Last updated on August 4, 2023

Peptides, the tiny but mighty building blocks of proteins have become a staple in anti-aging formulations.

Their significant ability to stimulate collagen and on the other hand, vitamin C, the beloved antioxidant is known for its brightening prowess whilst fading dark spots and protecting the skin from environmental damage.

Now, you can already picture the immense potential when these two skincare powerhouses join forces. 

We will show you how these ingredients combat aging, improve skin texture and tone and provide you with valuable insights on how to incorporate them into your daily skincare routine for maximum impact.

Prepare to be amazed!

What is The Role of Vitamin C in Skincare?

Vitamin C which is also known as ascorbic acid, is a powerful antioxidant that offers numerous benefits for the skin.

It induces collagen synthesis whilst helping to maintain the skin's structural integrity and reduce the signs of aging. And that is a thing we all want, right?

Vitamin C also acts as a brightening agent, fading dark spots and improving overall skin tone. Adding to that it also protects your skin from environmental damage caused by free radicals, UV rays, and pollution.

What Are the Benefits?

The remarkable benefits of vitamin C in skincare are unparalleled making it an irreplaceable step in your beauty routine.

Let's delve into the multitude of advantages that highlight just how potent and transformative this ingredient can be.

Anti-Aging Effects

In maintaining healthy-looking skin, several nutrients come into play. Among them is Vitamin C. Studies have shown that actually Vitamin C it’s crucial for stimulating natural production of collagen. 

Now, what is Collagen?

Collagen is a really important protein that is responsible for restoring elasticity in our skin’s structure. 

Over time this protein naturally declines and then we experience deep lines and wrinkles, saggy skin so basically the elasticity is lost.

In this part, vitamin C comes to the rescue and its role is to stimulate skin cells to produce more collagen. 

Research even demonstrates that topical application of vitamin C serves as an effective rejuvenation therapy whilst revitalizing the skin's appearance. [1]

Accelerated Wound Healing

In addition to its well-known dietary and skin benefits Vitamin C has crucial therapeutic benefits for wound treatment as well. 

Through its ability to regulate inflammatory responses and promote tissue growth; Vitamin C aids the body's natural healing processes efficiently.

Its antioxidant properties actively enhance the skin's response to injuries such as cuts or sunburns whilst simultaneously combating free radicals.

Free radicals are known as inhibitors of cell repair and growth processes within the body. Therefore Vitamin C is effective in reducing inflammation alongside alleviating burn related pain while expediting scab formation and scarring.

Brightening and Lightening Agent

The benefits of using vitamin C in achieving a brighter and lighter complexion are truly impressive.

Its potent ability to fight against free radicals is just one aspect - vitamin C also effectively manages melanin production, which is responsible for determining skin coloration. 

Overproduction of melanin can result in darker areas of the skin being formed especially when exposed excessively to harmful UV rays.

If you're looking for a way to reduce dark spots and improve your complexions evenness, look no further than vitamin C.

By facilitating chemical exfoliation instead of harsh physical scrubbing this nutrient aids in shedding dull skin cells and revealing a more vibrant and youthful glow.

Photoprotection Shield

Achieving optimal skin health often involves considering both preventative care measures alongside targeted treatment options.

In terms of prevention tactics against damaging effects from sunlight exposure or UV radiation, Vitamin C has proven itself. 

Acting as a powerful photoprotective agent - Vitamin C offers much-needed protection against issues such as photodamage including redness, pigmentation or discoloration. 

All of those are commonly associated with exposure to UVA/UVB rays. 

However- one should note that while including Vitamin C enriched topical products in your routine can have significant benefits - these items do not replace your primary need for broad-spectrum sun protection.

Always use SPF people!!! [2]

Corrects Hyperpigmentation and Redness

Hyperpigmentation or dark spots are not a source of frustration anymore––vitamin C offers impeccable aid via its contributions towards wound healing, collagen production (amongst other things). 

Furthermore, individuals experiencing conditions like rosacea will benefit from the powerful antioxidants and the anti-inflammatory characteristics. 

With consistent use of vitamin C on your skin you will definitely notice that the complexion becomes more evenly toned whilst also further discoloration is being prevented. [3]

What About Peptides?

Peptides are short chains of amino acids that are the building blocks of proteins. Proteins are essential components of our body performing a wide range of biological functions. 


Peptides are utilized for their ability to interact with the skin cells and promote specific functions. Different types of peptides have different functions and can target specific concerns such as collagen synthesis, skin firmness, hydration and wound healing.

One of the most well-known functions of peptides in skincare is their role in stimulating collagen production.

Here's a brief summary of the remarkable advantages they bring:

  • Collagen Boost

  • Skin Renewal

  • Moisture Retention

  • Anti-Aging Defense

  • Inflammation Reduction

  • Targeted Solutions

  •  Compatibility with Other Ingredients like Vitamin C

How Do Peptides and Vitamin C Work Together

Synergy Unleashed

What's better than one skincare ingredient?

Two combined!

Peptides work wonders on your skin by enhancing collagen production while vitamin C boosts its effectiveness by protecting against oxidative stress and encouraging collagen synthesis.

Together they create an unbeatable synergy that yields smoother looking skin with improved texture as well as restored firmness- talk about a win win situation!

Let’s delve deeper into more details on how does this combo really affects our skin, in the next paragraph!

Benefits of Using Peptides and Vitamin C Together

Collagen Synthesis

Maintaining youthful-looking skin requires us to pay attention to specific proteins like collagen, that provide structural support to the body tissue.

Peptides play a very critical role by stimulating the skin cells to produce more of this protein, thus improving skin elasticity significantly.

And on the other hand, Vitamin C aid enzyme reactions that convert amino acids into collagen strands.

That leads to optimum collagen production when collaborated with Peptides. When used together, you can achieve flawless and wrinkle-free smoothness.

Antioxidant Protection

As an antioxidant powerhouse Vitamin C neutralizes unstable molecules called free radicals.

Those often damage our epidermal cell structure causing premature aging and related issues such as dullness or uneven texture.

When combined with peptides Vitamin C becomes even more efficient at defending our bodies naturally whilst decreasing oxidative stress levels. An ideal combo for combating harsh environmental factors like pollutants and UV radiation.

Skin Brightening

Vitamin C has the ability to inhibit melanin production, the pigment responsible for dark spots and uneven skin tone. By reducing melanin synthesis vitamin C can help brighten the skin and improve its overall complexion. 

Peptides, on the other hand, contribute to skin exfoliation and renewal. Simultaneously, it also promotes the removal of dull, dead skin cells and revealing a more radiant and even toned complexion. 

The combined action of peptides and vitamin C results in a brighter and more luminous skin appearance.

Wound Healing

Peptides are gaining popularity as an effective solution for promoting tissue repair & regeneration. 

On the other hand, vitamin C continues to hold its ground as a key player in successful collagen synthesis. 

That makes it super important for proper wound closure & scar formation. In combination with each other (peptides + vitamin C) they make quite a powerful team! 

Together they greatly speed up the healing of common skin injuries like cuts, burns or acne scars so you'll be back to your best self in no time![4]

How Peptides and Vitamin C Combat Aging

Defying the Clock

Peptides play a crucial role in combating the signs of aging. By stimulating collagen production, peptides help to reduce the appearance of wrinkles and fine lines. 

They also promote skin renewal improving texture and minimizing the effects of environmental damage.

Meanwhile, Vitamin C acts as a potent antioxidant, neutralizing free radicals that contribute to premature aging.

It also aids in collagen synthesis maintaining the skin's structural integrity and reducing the signs of aging such as sagging skin and dull complexion.

How Peptides and Vitamin C Improve Skin Texture and Tone

To achieve flawless looking skin that feels soft & supple without any signs of rough textures or blemishes requires some extra TLC through top-rated skincare ingredients like peptides! 

These tiny powerhouses work wonders by stimulating collagen & elastin. At the same time vitamin C with its skin-brightening properties it can fade away stubborn dark spots and hyperpigmentation.

Now you can imagine what combining those two will benefit your skin!

How to Incorporate Peptides and Vitamin C into Your Skincare Routine?

  • Cleansing: Begin your skincare routine with a gentle cleanser to remove impurities and prepare your skin for the active ingredients to come.
  • Peptide Serum: Apply a peptide-rich serum to clean, dry skin.
    Look for serums with specific peptides like palmitoyl pentapeptide-3 or copper peptides which promote collagen synthesis and improve skin texture.
  • Vitamin C Treatment: Follow the peptide serum with a vitamin C treatment.

    Choose a stable form of vitamin C such as ascorbic acid or sodium ascorbyl phosphate, and apply it evenly to your face and neck. Give it a few minutes to absorb before proceeding.
  • Moisturizer: Seal in the benefits of the peptides and vitamin C with a nourishing moisturizer.

    Look for a moisturizer that complements your skin type and provides hydration without clogging pores.
  • Sunscreen: In the morning always finish your skincare routine with a broad-spectrum sunscreen with an SPF of 30 or higher.

    This step is crucial to protect your skin from harmful UV rays, which can accelerate aging and damage collagen.

Side Effects and Precautions

While peptides and vitamin C are generally safe for most, just like with other products you always have to be aware of potential side effects and take necessary precautions:

  • Sensitivity: Some of you may be sensitive to certain peptides or vitamin C derivatives. Perform a patch test before incorporating new products into your routine especially if you have sensitive skin or a history of allergies.
  • Irritation: Overuse or improper application of peptides or vitamin C can lead to skin irritation. Follow the recommended usage instructions and start with a lower concentration to assess your skin's tolerance.
  • Sun Sensitivity: Vitamin C can increase skin sensitivity to the sun. Ensure you wear sunscreen daily and limit sun exposure during peak hours to prevent sunburn and further damage.

Frequently Asked Questions

Can peptides and vitamin C be used together?

Definitely yes, peptides and vitamin C can be used together. In fact, their combination offers enhanced benefits for the skin like improved collagen synthesis and protection against oxidative stress.

Do you put vitamin C before or after peptides?

Apply peptides first allowing them to penetrate the skin and stimulate collagen production then follow with vitamin C to brighten the skin and provide antioxidant protection.

What do peptides and vitamin C do to the skin?

Peptides boost collagen production whilst improving skin elasticity and reducing the appearance of wrinkles. Vitamin C brightens the skin, fades dark spots and protects against environmental damage.

Should you take vitamin C with collagen peptides?

While both vitamin C and collagen peptides offer benefits for the skin, they work through different mechanisms. Taking them together may provide complementary effects supporting overall skin health.

Can I use vitamin C, retinol, and peptides together?

Yes, you can use vitamin C, retinol and peptides together. But keep in mind that you would have to introduce them gradually into your routine and monitor your skin's reaction. Start with lower concentrations and consider spacing out their usage to prevent irritation.


Peptides and vitamin C form an exceptional power duo in skincare delivering a multitude of benefits for the skin. 

Peptides stimulate collagen production improving skin firmness and reducing the appearance of wrinkles and fine lines. 

Vitamin C brightens the complexion, evens out skin tone and provides antioxidant protection against environmental stressors. 

When used together, peptides and vitamin C synergistically enhance each other's effects resulting in a more youthful, radiant and revitalized complexion.


1. The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach. Retrieved from

2. Topical Vitamin C in Skin Care. Retrieved from

3. Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. Retrieved from


About the author 

Dr Drilon Beloshi is a hardworking and passionate doctor who enjoys research, writing, and teaching. Conducted scientific research in the field of endocrinology.

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