6 Peptides for Weight Loss [Evidence-based]

Written by Drilon Beloshi | Last updated on August 4, 2023

Have you ever heard of peptides and wondered what they are and how they can help with weight loss? Well, you're in the right place!

Peptides are critical in many biological processes, such as cell communication, immune response, metabolism, energy production, and weight loss.

In this article, we’ll discuss what peptides are, their importance to our bodies, and how they can lead to successful and healthy weight loss when combined with dieting or exercise.

We'll also cover why purchasing good quality dietary supplements containing them is important so your body will benefit from incorporating them into your lifestyle. So pull up a chair - let's dive in!

Science of Peptides

Peptides are small proteins composed of two or more acids linked together in a chain found in cells and tissues of the body. This chain is called a peptide bond.[1]

These molecules play an important role in various biological processes, including cell communication, immune response, metabolism, and energy production. They can also be used for weight loss with proper dieting or exercise.

Peptides act as signal transmitters that send messages from one cell to another. They regulate a variety of processes in the body, such as appetite and energy production.

With a low-calorie diet, peptides can help reduce weight by decreasing food cravings and increasing metabolism.

Types of Peptides

Peptides are short chains of amino acids, which are the building blocks of proteins. Different types of peptides play different roles in our bodies, and they can have a profound effect on weight loss.


Dipeptides are two amino acids linked together, occurring naturally in our bodies. They have several roles in metabolism and fat burning, including aiding digestion, increasing the body's sensitivity to insulin, and preventing fat storage.


Tripeptides are three amino acids linked together. They help regulate metabolism and also promote fat burning. They help the body absorb nutrients, which can be used for energy production and weight loss.


Tetrapeptides are four amino acids linked together, and they help regulate appetite hormones such as ghrelin, leptin, and insulin. This helps to reduce cravings, prevent overeating, and keep your appetite in check.


Oligopeptides are longer chains of amino acids, typically 5-10 amino acids long. They are major in metabolism, fat burning, and energy production. They can also help to boost the body's natural ability to burn fat while preserving muscle mass.

Benefits of Peptides

Provides More Youthful Skin

One of the most significant benefits of peptides is that it helps keep skin youthful and healthy.

Peptides are known for increasing collagen production, which can help reduce signs of wrinkles, sun damage, and other age-related issues. This result can also be seen in improved muscle tone and elasticity.

Post-Workout Support

Peptides can also be used to support post-workout recovery. The body breaks down muscle fibers during workouts, and the acid-building blocks found in pets help restore it quickly by encouraging faster healing of muscles and tissue repair.

This aids in decreased fatigue, improved stamina and energy levels, and enhanced performance capabilities.

Improves Muscle and Joint Pain

Peptides are also known for improving joint and muscle pain. These molecules improve the overall health of joints and muscles by reducing inflammation, repairing tissue damage, and increasing mobility. This can be especially helpful in those experiencing arthritis and tendonitis.

Enhances Memory and Brain Function

Some peptides can help reduce the symptoms of aging in the brain, such as memory loss.

Peptides improve cellular communication, enhancing connections between neurons and increasing neuron growth, making it easier to remember things. 

This also helps with learning new information faster and more efficiently.

Boosts Sleep Quality

Peptides are also known to improve sleep quality. Melatonin is a peptide that helps regulate our natural sleep/wake cycle, promoting longer and deeper sleep. This can also help reduce stress levels, making relaxing and switching off at night easier.

Supports Healthy Libido

Lastly, peptides can help increase libido and improve sexual performance.

This is because they are involved in producing hormones such as testosterone, estrogen, and human growth hormone, which are important for regulating sex drive.

Peptides also support better circulation to help you become aroused more quickly.

Role of Peptides in Weight Loss

Peptides are small proteins that play an important role in our bodies. They have been found to have various beneficial properties, including aiding in weight loss.

Peptides help with weight loss by facilitating the breakdown of fat cells and improving metabolism and appetite suppression.

Regarding metabolism, peptides can improve the efficiency of our metabolism and help convert excess fat into energy.

This means that not only will you burn fewer calories and be less likely to gain weight, but your body will also be better able to break down the fats it stores.

Furthermore, peptides play a role in appetite suppression. Peptides act on the brain to reduce hunger and cravings, making you less likely to overeat or snack between meals.

In addition, peptides can help regulate hormones responsible for hunger, helping to ensure that your body feels full sooner.

Peptides can effectively lose weight with a healthy diet and regular exercise.

They provide the body with the extra support needed to successfully shed unwanted fat and allow you to maintain healthy weight management in the long term.

Popular Peptides For Weight Loss


CJC-1295 is a peptide with many benefits for weight loss, including increased energy levels, improved metabolism, and decreased fat storage. 

It works by stimulating the release of Growth Hormone Releasing Hormone (GHRH), which increases your body's growth hormone production. This increase in growth hormone secretion helps promote the breakdown of fatty acids, leading to increased fat burning. [3]


GHRP-6 is one of the most common peptides used in weight loss supplements. It increases ghrelin levels, known as the hormone, and stimulates a stronger release of growth hormones from the pituitary gland. 

This, in turn, helps burn fat and build muscle. GHRP-6 is effective in helping reduce body fat and increase lean muscle mass.


Ipamorelin works by stimulating the natural growth hormones. This boosts fat metabolism, burns fat cells more efficiently, and regulates body composition.

This can help you reach your weight loss goals faster. As you age, your body’s production of these hormones naturally declines. However, ipamorelin can help reverse the damage that comes with age.

In addition to helping you lose weight more effectively, ipamorelin also helps promote muscle growth and tissue repair.

This means it helps you shed fat and builds up muscle mass. This increases your metabolic rate and stimulates your body to use excess fat for fuel [4].

Melanotan 2.

One of the most popular peptides used for weight loss is Melanotan 2 (MT2). MT2 has been found to stimulate melanocyte receptors and help with skin pigmentation, making it a popular choice for weight loss.

MT2 specifically helps by stimulating the MC4 receptors in the brain and body, which can increase satiety after a meal and reduce appetite-stimulating hormones like ghrelin from being released.

Additionally, it acts as an agonist of the MC1 receptor, which helps promote fat burning to target areas that may be difficult to lose weight.

Mod GRF 1-29

Modified GRF (1-29), often abbreviated as mod GRF (1-29) or simply GRF, is an important peptide used with dieting and exercise to help weight loss. 

Mod GRF 1-29 is a modified version of the shortest fully functional fragment of growth hormone releasing factor (1-29), or “sermorelin,” which stimulates the release of our body’s growth hormone.

By stimulating the body’s natural production of GH, Mod GRF 1-29 helps to encourage fat breakdown and can help promote weight loss.


One type of peptide gaining attention for its potential to promote weight loss is PT-141. It is a peptide derived from the hormone Melanotan II that works by activating melanocortin receptors in the brain, leading to increased energy expenditure and reduced food intake.

PT-141 also has potential anti-depressant effects, which may help reduce cravings and emotional eating.

PT-141 can help individuals achieve lasting weight loss with dietary changes and regular exercise. However, purchasing a high-quality supplement containing this peptide is important for your body to benefit from its effects.

Types of Administration

There are a few different methods when administering peptides for weight loss.

Subcutaneous injection 

The most popular form of administration is subcutaneous injection, which involves injecting the peptide directly into the skin. 

This method allows the peptide to be quickly absorbed by the body, allowing faster and more effective results. However, it can be uncomfortable for some people and requires regular injections [5].

Oral Administration

Another option is oral administration, which involves taking the peptide in pill or capsule form. This method is much less intrusive than injections but takes longer to absorb into the body, meaning results may take longer to see [6].


A third form of administration is transdermal, which involves applying the peptide to the skin. This method is best for people who don’t want injections but still prefer a faster route of absorption. 

However, finding the right formula and application process for your body type to get optimal results can be tricky.

No matter which form of administration you choose, it is important to use a high-quality peptide supplement for your body to take advantage of all its benefits. 

Make sure you research and purchase from a reputable company to know you are getting the most out of your investment in weight loss.

Recommended Dosage

Including peptides in your weight-loss program can help you reach your goals faster, but using the correct dosage is important. 

Appropriate peptides will depend on various factors, including age, body weight, and overall health.

As always, it is best to consult your doctor before adding any new dietary supplement.

Regarding peptides for weight loss, the most common dosage recommendation is 500-1000 milligrams daily, divided into two or three doses throughout the day.

It is important to note that taking too much can lead to side effects like:

  • The feeling of fullness
  • Heartburn
  • Bad taste in my mouth.
  • Rashes
  • Itching
  • Swelling
  • Redness of the injection site. [7]

When to take peptides and duration of use

Peptides are a great way to lose weight, but it’s important to understand when and how to use them. Peptides should be taken at least 30 minutes before meals or exercise to ensure the body has time to absorb them.

The duration of peptide supplementation depends on individual goals but generally ranges from four to six weeks. After this period, a break of at least four weeks should be taken before restarting the cycle if desired.

Benefits of Using Peptides for Weight Loss

Boosts Energy Levels

Peptides can help boost energy levels by fat oxidation, which benefits those who want to lose weight.

They work by stimulating the body’s cells to burn fat faster and more efficiently. This gives you more energy, allowing you to exercise longer and harder, resulting in greater weight loss. 

Building Lean Muscle Mass and Enhancing Strength

Peptides can help build lean body mass and enhance strength, which benefits those looking to lose weight. 

They work by stimulating protein synthesis in the body, allowing the body to produce more amino acids that are necessary for muscle growth.

This can increase muscularity and strength, enabling you to burn more calories during exercise and aiding your overall weight loss goals. 

Balances Hormones

Peptides can help balance hormones related to weight gain, making it easier for the body to maintain a healthy weight.

They regulate hormonal production, which helps keep insulin, leptin, and ghrelin levels in check. This can result in better appetite control and reduced cravings, promoting healthy eating habits and aiding in weight loss goals. 

Reducing Inflammation

Peptides can help reduce inflammation, which has been linked to obesity. They work by inhibiting the production of cytokines, which are molecules that cause inflammation in the body. 

This can reduce inflammation throughout the body, making losing weight and maintaining a healthy body easier. 

Frequently Asked Questions

Do peptides work for weight loss?

Peptides help with weight loss when combined with a healthy diet and exercise.

Incorporated into your daily routine, they can help boost fat-burning capabilities and increase physical energy so you can stay motivated in your weight loss journey.

How long does it take to lose weight on peptides?

The amount of weight you can lose with peptides depends on your lifestyle and diet. On average, it can take anywhere from a few weeks to several months to achieve optimal results.

What are the side effects of using peptides?

The side effects of using peptides are generally mild and may include nausea, headaches, and skin irritation.

How much do peptides cost for weight loss?

The cost of peptides for weight loss depends on the quality and quantity of the product.

Generally, good-quality peptide supplements are reasonably priced online or in health stores.

Can I buy peptides over the counter?

Yes, peptides are widely available for purchase over the counter. However, it is important to make sure you buy them from a reputable source so that you know that they are safe and of good quality.

What do you avoid when using peptides?

It is important to avoid consuming foods that are processed or high in unhealthy fats, sodium, and sugar while using peptides. Getting enough sleep every night and drinking plenty of water is also important.

Who should not take peptides?

People with pre-existing medical conditions, such as kidney or heart disease, should not take peptides without consulting their doctor. Pregnant and breastfeeding women should also avoid taking peptides.


Peptide therapy can be a great aid and supplement to weight loss. It helps you lose fat and builds and maintains muscle mass.

The use of peptides for weight loss has gained prominence in recent years because it can help provide a more defined muscle tone. 

To maximize the effects of peptides for weight loss and get desired results, it is vital to understand how this process works, which peptides are used, their benefits, and their recommended doses and administration routes. 

When used properly and monitored regularly through blood tests or with an endocrinologist's assistance, peptide therapies can produce helpful results for your overall health and well-being.


  1. Do Peptides Work For Weight Loss, retrieved from https://healthnews.com/nutrition/vitamins-and-supplements/do-peptides-work-for-weight-loss/
  2. Peptides for weight loss and 10 cutting-edge health benefits, retrieved from https://centerforwell.com/peptides-for-weight-loss-and-10-cutting-edge-health-benefits/ 
  3. The best peptides for weight loss, retrieved from https://reliefbeginshere.com/the-best-peptides-for-weight-loss/ 
  4. Peptides for weight loss: Everything you need to know. Retrieved from https://reliefbeginshere.com/the-best-peptides-for-weight-loss/ 
  5. The Complete Guide to Peptide Therapy for weight loss. Retrieved from https://lowcountrymale.com/peptide-therapy-weight-loss/ 
  6. Do Peptides work for weight loss? Retrieved from https://healthnews.com/nutrition/vitamins-and-supplements/do-peptides-work-for-weight-loss/ 

About the author 

Dr Drilon Beloshi is a hardworking and passionate doctor who enjoys research, writing, and teaching. Conducted scientific research in the field of endocrinology.

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