How Long Does Rhodiola Rosea Stay in Your System?

Written by Salma Younas | Last updated on August 4, 2023

The popularity of Rhodiola rosea as an herbal remedy prompts us to investigate how long it lasts within the human body. 

We aim to provide a full understanding of its benefits during the average span of 4-6 hours that it remains active, including key areas such as metabolism rates along with potential drug test outcomes.

This article is based on research led by scientists who specialize in herbal medicine to establish a solid foundation for our content. 

Through gaining insights into Rhodiola rosea intricacies we aim to enhance your comprehension and assist you in navigating its effects with ease.

In this article, we explore Rhodiola's key components that make it bioactive alongside how it metabolizes in the body. 

We also examine factors that influence its duration as well as half-life and detectability in drug tests. Additionally, to help you manage intake better, we offer some tips alongside highlighting possible interactions with other medications which can cause side effects.

What is Rhodiola Rosea?

Rhodiola rosea (also known as Rhodiola rosea L.), inhabits regions with frigid temperatures such as North Americas mountains and parts of Europe & Asia along with the Arctic, classified under the genus Rhodiola. 

These perennial flowering plants belong to the Crassulaceae family of flora [1].

Rhodiola rosea is used to enhance cognitive and physical performance capacity, ease anxiety symptoms uplift mood and energy levels. 

These herbs' appeal lies in their ability to support overall well-being in an all-natural manner - attracting individuals looking for such alternatives to deal with daily pressures [2, 3].

Bioactive Components of Rhodiola Rosea


The adaptogenic features (a healthy stress response) of Rhodiola rosea are related to a class of substances called rosavin.

Three main types of rosavins--rosavin, rosin, and rosarin--are abundant in this herb. Evidence suggests that these specific compounds may support anti-stress and anti-fatigue outcomes [4].


Salidroside, a glycoside that is recognized as one of the foremost active constituents in this herb provides several beneficial properties for overall well-being. With antioxidant and anti-inflammatory effects, it also possesses neuroprotective capabilities [4].


Rhodiola rosea is also rich in various polyphenolic compounds including flavonoids besides proanthocyanidins which contribute to its notable antioxidant and anti-inflammatory attributes. In this context, they significantly aid in cell protection against reactive oxidative species [5].

Metabolism of Rhodiola Rosea in the Body

When Rhodiola rosea is consumed, its bioactive components are metabolized within the body via various processes that have a significant effect on its presence and impact duration.

Gaining familiarity with Rhodiola rosea's metabolic pathways offers essential insights into its longevity within our system and overall effectiveness.

Following ingestion, Rhodiola rosea's bioactive ingredients go through absorption from our gastrointestinal tract to enter our bloodstream. At this stage, these elements spread out in various regions of the body before ultimately reaching their sites of action where their positive effects manifest.

Enzymatic reactions, including glucuronidation and sulfation, are involved in Rhodiola rosea metabolism taking place in the liver.

Transformed into metabolites, these compounds are eventually excreted from the body via urine or feces after transportation to biliary or renal pathways [6].

Factors Affecting the Duration of Rhodiola Rosea in Your System

Dosage and Frequency

The length of time that Rhodiola rosea lingers in your system is influenced by the quantity and frequency of ingestion.

Repetitive use of these supplements could lead to their buildup within your body which results in a prolonged period of their presence.

Individual Metabolism

Each person's metabolism varies, affecting how Rhodiola rosea is processed by the body. Alongside this factor are age, liver function, and overall health which can determine the level of impact on one's metabolic rate.

Formulation and Preparation

It is important to carefully evaluate how the formulation and preparation process affects the bioavailability and absorption of Rhodiola rosea products. 

By utilizing standardized extracts with unique concentrations of active compounds we may observe greater absorptive capacity relative to raw herb preparations.

Co-Administration of Other Substances

Other compounds within the body have been shown to potentially affect Rhodiola roseas metabolism.

Such compounds can range from herbal supplements to prescribed medication both of which could impact the responsible enzymes and alter how long it remains present within the system.

Half-life of Rhodiola Rosea

Half-life is the duration required for a substance's concentration within our bodies to reduce by 50%.

Although determining exactly what this means for Rhodiola rosea could pose some difficulties due to constraints such as scarce scientific data and disparities in each individual's metabolic rates.

It has been found that such disparities result in varied ranges –between 12 and 24 hours- necessary for clearing out fifty percent of active compounds within our systems after consumption.

However, even with such knowledge of Rhodiola half-life, its effects do not persist over the same duration [7].

The active compounds present within this compound typically remain detectable within one's body for approximately 4 to 6 hours with complete expulsion requiring 2 to 3 days.

Detectability of Rhodiola Rosea in Drug Tests

The vast majority of routine drug tests typically don’t consider Rhodiola rosea since it isn't regarded as a controlled substance so its active substances aren't regularly screened during typical drug testing procedures.

To tread on the side of caution regarding urinalysis tests we suggest that anyone who frequently ingests Rhodiola rosea cease its use at least several days before their examination. 

Doing so would provide enough room for the bioactive components of this supplement to exit the body completely and reduce any chance of misinterpretation or false positives in your results.

Duration of Effects from Rhodiola Rosea

The reputation of Rhodiola rosea as a promoter of general wellness stems from its prospective health benefits and constructive influences. 

Nevertheless, the duration for which these effects last may depend on numerous factors like individual metabolism, dose ingested and frequency consumed.

Short-term Effects

Following ingestion of Rhodiola rosea, most individuals experience its positive effects ranging between 30 minutes to one hour later. 

Typically speaking approximately two or three hours after consumption, the effects may persist for several hours afterward but some level of variability exists among different people's responses.

Immediate improvements in mental alertness, cognitive function improvement and heightened focus/ concentration can be observed alongside a marked reduction in feelings of fatigue alongside feeling better overall with lower stress levels-all particularly appreciated during intense periods of work [8].

Long-term Effects and Cumulative Benefits

Rhodiola Rosea has shown significant promise for those who implement consistent use over an extended period. 

Benefits such as improved mood regulation with decreased feelings of anxiety/depression; better physical performance abilities; heightened resilience against stress are some of the positive outcomes observed with prolonged use of this herb. 

Furthermore, this supplement boosts your body’s adaptive capabilities leading to a balanced state while promoting excellent general health [9].

Tips for Managing Rhodiola Rosea Intake

Doctor Consultation

Consult with a Healthcare Professional

Healthcare providers are available to analyze your wellness condition address any concerns about potential interactions with medications or pre-existing medical issues and suggest personalized guidance about dosing and duration.

Start with a Low Dosage

Taking on this method permits you to measure your reaction and endurance to the herbal component. In addition, starting with a low dosage decreases the chance of any potential unfavorable afflictions.

Follow Recommended Dosage Instructions

To ensure safety and maximize potential benefits it is crucial to follow either the manufacturer's suggested dosage or your healthcare professional's advice regarding dosage.

Taking beyond what is advised could lead to undesired effects without necessarily providing extra advantages.

Consider the Timing of Intake

Rhodiola rosea has been known to enhance concentration levels boost energy levels and improve overall mental acuity when consumed early in the day.

Nonetheless, each individuals lifestyle habits and tastes differ significantly; thus it's necessary to find a prompt that perfectly suits their circumstances.

Monitor Your Response

As you consume Rhodiola rosea pay attention to variations in mood swings and increased energy levels which may lead to disturbances in normal sleeping patterns as well as physiological issues which should be closely monitored over the intake period.

Avoid Prolonged Continuous Use

Though considered safe by experts it's best to refrain from using Rhodiola rosea without periodic breaks as this can lead to developing tolerance towards this herbal medicine over time.

Taking such measures could help maintain its potency throughout extended usage while also avoiding potential side effects associated with 'stacking'.

Rhodiola Rosea and Drug Interactions

Antidepressant Medications

Supplements like Rhodiola Rosea can pose significant health risks if taken without due consideration for people suffering from depression who also use specific antidepressants such as selective serotonin reuptake inhibitors (SSRIs) or monoamine oxidase inhibitors (MAOIs). 

The two substances combined could trigger potentially life-threatening conditions that manifest in symptoms like rapid heartbeat, agitation, high blood pressure, and confusion - this is called serotonin syndrome [10].

Blood Thinners

Since Rhodiola has natural properties that mildly thin the blood its consumption alongside anticoagulant or antiplatelet drugs like warfarin and aspirin can potentially elevate the risk for bleeding. 

If you're already on a course of medication for treating bleeding disorders or use anticoagulants as part of your medical routine plan consult your doctor before integrating Rhodiola rose into your routine [11].

Diabetes Medications

Rhodiola rosea can potentially have a hypoglycemic effect or decrease glucose levels.

But when paired up with other anti-diabetic measures such as oral hypoglycemic agents or insulin therapy may raise concerns related to intensified glucose-lowering effects - potentially leading to conditions like low blood sugar which require careful monitoring. 

In such circumstances, regular checkups of blood sugar levels is essential [12].


Rhodiola rosea has been shown to possess qualities that can incite stimulatory responses within the body. 

But when paired with other stimulating agents like caffeine or medication used to treat ADHD it raises concerns for an increased risk of being overly stimulated and experiencing unwanted effects on cardiovascular health [13].

Other Herbal Supplements

It is worth noting that Rhodiola rosea could interact with other herbal supplements that produce similar effects, such as ginseng or St. Johns wort. 

If these substances are utilized together it may heighten their respective impacts or create a greater potential for unwanted reactions.

Potential Side Effects of Rhodiola Rosea

Woman standing with digestive sensitivity and presses her hand on her stomach

Even though uncommon, below are some possible adverse effects [14]

Allergic Reactions

It should be noted that an allergy to Rhodiola rosea is rare. 

However, if you begin experiencing discomforts such as rash, itchiness, inflammation or breathing difficulties following its consumption - ceasing its use promptly and reaching out for professional medical aid will certainly hasten recovery.

Digestive Upset

While relatively rare, some people experience mild digestive discomfort such as nausea, stomach upset or diarrhea after taking Rhodiola rosea. 

Usually temporary and subside by themselves without any further intervention needed. However symptom persistency calls for stopping the use of this herb together with seeking medical advice from a healthcare professional.

Insomnia or Restlessness

It is worth noting that stimulating properties are present in Rhodiola rosea which could cause heightened alertness and interfere with sleep patterns for some individuals. 

If such complications do arise after consumption of this supplement, reduce intake or steer clear from consuming close to bedtime.

Increased Blood Pressure

Rhodiola rosea has been associated with a possible mild increase in blood pressure. 

For individuals who have hypertension or are taking medications to regulate high blood pressure, it is crucial to carefully monitor their blood pressure levels while using Rhodiola rosea.

Frequently Asked Questions

How long does it take for Rhodiola to kick in?

Rhodiola rosea usually produces noticeable effects within half an hour to one hour of consumption, although people's reactions may differ.

How late in the day can you take Rhodiola?

For optimal nighttime rest experts advise against taking Rhodiola rosea too close to bedtime. Instead consuming it earlier on in the day - particularly during morning or early afternoon hours - is preferred.

Can you just stop taking Rhodiola?

Halting intake of Rhodiola rosea can be done whenever you see fit. Provided that you have used this supplement consistently, allowing your system wherewithal and time to adjust can be aided through reducing the dosage gradually over an extended period.

What does Rhodiola do to the brain?

The herb Rhodiola rosea may provide several advantageous effects for the brain like better cognitive ability and increased mental alertness alongside reduced tiredness levels. 

Also worth mentioning is its potential ability to support healthy stress management essential for overall mental well-being.

What not to take with Rhodiola?

Rhodiola rosea may interact with certain medications, such as antidepressants, blood thinners, or diabetes medications. It is important to consult with a healthcare professional to determine if there are any specific contraindications or precautions based on your circumstances.

Can I drink coffee while taking Rhodiola?

When Rhodiola rosea is combined with caffeine, there could be a higher stimulant effect. 

Ensure that you closely monitor your response while being mindful of modifying your caffeine intake should you face overstimulation or undesirable impacts.

Why take Rhodiola on an empty stomach?

Consuming it before eating will enhance the absorption and efficacy of Rhodiola rosea. However, those with digestive discomfort or simply wishing to take it with food can opt for a light meal alongside intake.


Rhodiola Rosea is packed with immense health-promoting benefits and offers great improvements overall. 

Following consumption, the metabolic processes determine how long it remains within your system. How effective the outcomes are will depend on personal metabolic rates, dosage and frequency. 

Optimal usage practices should guide its intake, some of the factors include dosage monitoring, picking out ideal administration schedules aside from potential interaction risks while being aware of side effects that may occur during persistent usage. 

It is strongly advised to consult with qualified medical experts who possess professionalism and expertise to ensure maximum safety while making use of Rhodiola rosea effectively.


1. An Overview on Rhodiola rosea in Cardiovascular Health, Mood Alleviation, and Energy Metabolism. Retrieved from

2. Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial. Retrieved from

3. Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms. Retrieved from

4. Assessing the Quality and Potential Efficacy of Commercial Extracts of Rhodiola rosea L. by Analyzing the Salidroside and Rosavin Content and the Electrophysiological Activity in Hippocampal Long-Term Potentiation. Retrieved from

5. Rhodiola plants: Chemistry and biological activity. Retrieved from

6. Effects of Two Different Rhodiola rosea Extracts on Primary Human Visceral Adipocytes. Retrieved from

7. The Effect of Acute Rhodiola rosea Ingestion on Exercise Heart Rate, Substrate Utilisation, Mood State. Retrieved from

8. Effects of Short-Term Golden Root Extract ( Rhodiola rosea). Retrieved from

9. The Effectiveness of Rhodiola rosea L. Preparations. Retrieved from

10. Mania Associated With Rhodiola Rosea: An Adaptogen With Antidepressant Effects. Retrieved from

11. Rhodiola,and%20some%20anti%2Dinflammatory%20drugs.

12. The impact of Rhodiola rosea on biomarkers of diabetes. Retrieved from

13. Rhodiola Rosea,and%20some%20anti%2Dinflammatory%20drugs.

14. Rhodiola



About the author 

Salma is an experienced community pharmacist who's worked at multiple well-known pharmaceutical companies including Dynatis Limited and Medipak Limited

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