5-Amino-1MQ: Game Changer in Weight Management?

Written by Drilon Beloshi | Last updated on August 7, 2023

5 Amino-1MQ has become a hot topic in discussions around metabolic health, weight management, and even cancer research. 

What is it and how could it benefit you?

Read on to learn about the science, potential benefits and growing intrigue surrounding 5-Amino-1MQ. 

What is 5-amino-1MQ and NMNT?

5-Amino-1MQ is a molecule that has been gaining attention in the scientific community for its potential applications in treating metabolic disorders and certain types of cancer.

It acts by blocking an enzyme called Nicotinamide N-methyltransferase (NNMT), which is involved in several metabolic processes in the body.

NNMT participates in the methylation of nicotinamide (a kind of vitamin B3), which changes nicotinamide to 1-methylnicotinamide. 

This mechanism depletes S-adenosylmethionine (SAM), a universal methyl donor involved in the methylation of many substances in the body. NNMT indirectly regulates numerous metabolic pathways by depleting SAM.

In the context of obesity, NNMT reduces the amounts of its substrates, specifically nicotinamide adenine dinucleotide (NAD+), a coenzyme that is essential for cellular metabolism and energy production. 

5-Amino-1MQ is hypothesized to boost NAD+ levels by blocking NNMT, hence improving metabolism and energy expenditure.

Is 5-Amino 1MQ an Effective Weight Loss Peptide?

Yes, some evidence from preclinical studies suggest that 5-Amino 1MQ can help with weight loss. 

The theory is that 5-Amino-1MQ can boost levels of NAD+ (Nicotinamide Adenine Dinucleotide), a critical coenzyme involved in many metabolic activities, including those that regulate energy expenditure, by inhibiting NNMT [1]. 

This has the potential to boost metabolism and energy expenditure, which could aid in weight loss.

How 5-amino-1MQ Works

5-Amino-1MQ is a small chemical designed to suppress the activity of an enzyme known as Nicotinamide N-methyltransferase (NNMT).

NNMT plays a role in the body's metabolic processes. It works by transferring a methyl group from S-adenosylmethionine (SAM), a universal methyl donor molecule, to nicotinamide (a form of vitamin B3), converting it into 1-methylnicotinamide. 

This process uses up SAM and indirectly influences various metabolic processes.

5-Amino-1MQ may improve the availability of SAM for other methylation processes in the body by suppressing NNMT. 

Furthermore, 5-Amino-1MQ is hypothesized to boost levels of NAD+ (Nicotinamide Adenine Dinucleotide), a critical coenzyme involved in many metabolic activities, including those that regulate energy expenditure, by inhibiting NNMT. 

This has the ability to boost metabolism and energy expenditure.

Potential Benefits of 5-amino-1MQ

Enhanced Metabolism

5-Amino-1MQ can potentially enhance levels of NAD+ (Nicotinamide Adenine Dinucleotide), a critical coenzyme involved in numerous metabolic activities, by inhibiting NNMT. 

This may improve metabolism and energy expenditure, which may aid in weight management and overall metabolic health [2].

Potential Anti-Cancer Effects

NNMT has been discovered to be overexpressed in a variety of cancers. 5-Amino-1MQ may have anti-cancer properties by suppressing NNMT. More research is needed, however, to fully comprehend its potential as a cancer treatment [3].

Potential Anti-Aging Effects

NAD+ levels decline with age, and this decline is linked to a variety of age-related illnesses and symptoms. 5-Amino-1MQ may have anti-aging properties by potentially raising NAD+ levels. More research, however, is required to establish these effects [4].

Potential Neuroprotective Effects

Some evidence suggests that NNMT inhibitors, such as 5-Amino-1MQ, may have neuroprotective benefits, perhaps aiding in the prevention of neurodegenerative disorders. However, this is based on early findings, and more research is required.

Associated Side Effects of 5-Amino-1MQ

In preclinical trials, 5-Amino-1MQ was usually well tolerated. However, without extensive clinical trials in humans, it is difficult to predict what negative effects may develop with its use.

Potential side effects could conceivably be related to its mode of action.

For example, by blocking the enzyme Nicotinamide N-methyltransferase (NNMT), 5-Amino-1MQ may alter several metabolic processes in the body, perhaps leading to unanticipated side effects.

It's also worth noting that the safety of 5-Amino-1MQ in specific populations, such as pregnant or breastfeeding women, children, or people with certain health issues, is unknown.

As with other substances, 5-Amino-1MQ should be used under the guidance of a healthcare practitioner.

Always get the advice of a healthcare practitioner before beginning any new medicine or supplement regimen. Misuse of drugs such as 5-Amino-1MQ might result in major health consequences.

Research on 5-Amino 1MQ

Study 1: Research in mice given 5-Amino 1MQ showed a 7% reduction in body mass over 10 days without any changes in food intake, compared to controls. Studies in mice over just 10 days of 5-Amino 1MQ administration reveal a 7% reduction in rate and a 30% reduction in fat mass. In addition, blood cholesterol levels in treated mice are equal to those of non-obese mice.

Study 2: 5-Amino 1MQ taken in conjunction with a low calorie or ketogenic diet can result in increased fat burning/body fat consumption over time. It is recommended to commit to 2-3 months of 5-Amino to see results [2].  


5-Amino 1MQ is available in capsule form and is chemically stable, allowing for oral administration.

The peptide is selective membrane-permeable, allowing it to be digested and enter the bloodstream and cells.


The general guidelines for regular 5-Amino 1MQ dosing to reap optimal benefits is 50 mg taken 1-3 times per day – preferably with meals. 

5-Amino 1MQ taken in conjunction with a low calorie or ketogenic diet can result in increased fat burning/body fat consumption over time. It is recommended to commit to 2-3 months of 5-Amino to see results.

After a time of use, it is recommended to take a one-month break from 5-Amino 1MQ.

Frequently Asked Questions

What is the half life of 5-Amino-1MQ?

The molecule appears to exhibit a linear kinetic behavior in mouse plasma, with a half-life of 5.7 hours.

What hormone is released for fat loss?

There are 5 main hormones that are released for fat loss: Insulin, Leptin, Ghrelin, Estrogen and Growth Hormone. 

Insulin: Insulin is one of the most important hormones when it comes to weight loss and weight gain. Made by the pancreas, insulin is responsible for storing blood sugar.

Leptin: Leptin is a hormone produced by fat cells in the body that helps regulate fat storage and how many calories are eaten and burned. It is often referred to as the “satiety hormone” or the “starvation hormone.” 

Leptin’s primary target is in the brain, particularly an area called the hypothalamus. Leptin reduces a person's appetite by acting on specific centers of their brain to reduce their urge to eat.

Ghrelin: Ghrelin is essentially the opposite of leptin. It's the hunger hormone that sends a message to the hypothalamus indicating that the stomach is empty and that it's time to eat.

Estrogen: Produced within the ovaries, estrogen is responsible for optimal functioning of all female reproductive organs. 

Estrogen promotes the storage of fat for healthy reproductive years. When estrogen is balanced, the right amount of fat helps carry out female reproductive functions. However, when there’s too little or too much estrogen, weight gain can occur.

Growth hormone: Growth hormone influences appetite, metabolism, and body fat distribution. It is produced by the pituitary gland and is responsible for growth and development in children and adolescents. In adults, it helps maintain muscle mass and bone density, and promotes fat loss.

How much weight can you lose with peptides?

Peptide therapy is a science-backed way to shed weight and enjoy other transformative benefits like improved sleep quality, younger-looking skin, and more energy. 

The amount of weight you lose will depend on many factors including your daily habits, diet, genetics, metabolism etc. In one of the clinical trials, Semaglutide resulted in a 15% body weight loss. 

Is it OK to take amino acids everyday?

Overall, amino acids are generally safe to use every day, as long as they're not consumed in huge amounts. The amount of amino acids needed per day varies depending on factors such as body weight, muscle mass, and activity level.

What are the cons of taking amino acids?

Imbalance: Extended use of amino acid supplements can cause the body to become out of balance

Taste: Some amino acid supplements may have a taste that is not enjoyable

Lack of research: There is a lack of available research on the safety and efficacy of amino acid supplements, so it is wise to avoid taking them until discussing with a doctor

Interaction with medications: Amino acid supplements may interact negatively with certain medications, so it is important to inform your doctor of any medications you are taking


To conclude, 5-Amino-1MQ is an intriguing molecule that has shown potential in preclinical studies for influencing metabolic processes and energy expenditure, which could potentially aid in weight management. 

However, while the potential of 5-Amino-1MQ is exciting, it's not currently recommended for individuals to try it for weight loss outside of a research setting. 

Weight loss should be approached holistically, including a balanced diet and regular physical activity, rather than relying solely on supplements or medications. 

Always consult with a healthcare professional before starting any new medication or supplement regimen.


  1. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826726/ 

  2. Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice. Retrieved from https://www.nature.com/articles/s41598-021-03670-5 

  3. Preclinical testing of 5-amino-1-((1R,2S,3S,4R)-2,3-dihydroxy-4-methylcyclopentyl)-1H-imidazole-4-carboxamide: a potent protein kinase C-ι inhibitor as a potential prostate carcinoma therapeutic. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287896/ 

  4. 5-Amino-1MQ: A Novel Anti-Aging Compound. Retrieved from https://issuu.com/genemedics/docs/5-amino-1mq_a_novel_anti-aging_compound.pptx 

About the author 

Dr Drilon Beloshi is a hardworking and passionate doctor who enjoys research, writing, and teaching. Conducted scientific research in the field of endocrinology.

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